سال انتشار: ۱۳۸۵

محل انتشار: سیزدهمین کنفرانس مهندسی پزشکی ایران

تعداد صفحات: ۸

نویسنده(ها):

Maysam Mashhadimalek –
Farzad Towhidkhah –
Shahriar Gharibzadeh –
Mohammad Ali Ahmadi-pajouh –

چکیده:

In this research, we evaluate the
inter-relation of tremor and rigidity in order to findwhether they are the two sides of the
same coin in Parkinson’s disease (PD). We includethe agonist and antagonist skeletal muscle models as well as the peripheral (spinal andlong loop reflexes) and central
(basal ganglia and cortex) mechanisms and try topresent a complete model of PD. All of
our simulation is developed in SIMULINK,
MATLAB 7.For simulating the muscle dynamics, we used the mechanical model of Hill. Input ofthe model is from CNS and the output is angular movement.The agonist and antagonist muscles are used simultaneously to simulate the tremorand its relation to the rigidity.Our abstract model of Basal ganglia is able to simulate the physiological tremor.
Voluntary co-contraction of muscles increases the tremor, which is physiologically
plausible. The model is also able to produce The PD rest tremor. Our results showedthat increased supplementary motor area output increases the rigidity. Finally ourmodel indicated that Rigidity worsens the tremor and vice versa.We suggest that the treatment of these two abnormal motor behaviors must befulfilled simultaneously. It seems that curing one of these two symptoms withoutdecreasing the other is not realistic. It is worth noting that experimental studies areneeded to validate this computational model.