سال انتشار: ۱۳۸۲
محل انتشار: هشتمین کنگره ملی مهندسی شیمی ایران
تعداد صفحات: ۴
Taghizadeh – Novel Drug Delivery Systems Department, Science Faculty, Iran Polymer and Petrochemical Institute, Tehran, I.R.Iran
Lahootifard – Novel Drug Delivery Systems Department, Science Faculty, Iran Polymer and Petrochemical Institute, Tehran, I.R.Iran
Different amounts of two skin permeation enhancers, Oleic acid (OA) and propylene glycol (PG), were mixed thoroughly with solution of an acrylic copolymer pressure sensitive adhesive (PSA). Films with adhesive layer thicknesses 30μ, were prepared by casting of the mixed solutions with a film applicator on PET 80μ films followed by drying of solvents. The results of peel test were explained on the basis of changing of entanglement molecular weight (Me) of the copolymer. PG, with no significant effect on Me, did not affect on the peel strength.. OA decreased the peel strength, specially when concentration exceeded 5(w/w%). This was explained on the basis of formation of a weaker surface layer and effective thickness decrease. Cohesive failure OA samples occurred at above 15(w/w%) .