سال انتشار: ۱۳۸۴

محل انتشار: دهمین کنگره ملی مهندسی شیمی ایران

تعداد صفحات: ۸

نویسنده(ها):

Houman Savoji – Chemical & Petroleum Engineering Department, Sharif University of Technology
Ramazani – Chemical & Petroleum Engineering Department, Sharif University of Technology
Mehdizadeh – 2Hakim Pharmaceutical Co

چکیده:

Different drug in adhesive patches (DIAPs) of nitroglycerin were formulated using various pressure sensitive adhesives (PSAs) and various chemical permeation enhancers (CPEs). The effects of the PSAs and CPEs on skin permeation of nitroglycerin from DIAPs were evaluated
using modified jacketed Franz diffusion cells fitted with excised rat abdominal skins. It was demonstrated that permeation rate or steady state flux (Jss) of the drug through the excised rat skin was dependent on the viscosity and type of acrylic PSA as well as the type of CPE. Among
different acrylic PSAs, Duro-Tak® ۲۵۱۶ and Duro-Tak® ۲۰۵۱ showed the highest Jss 200.8 µg cm-2 h-1 and lowest Jss 112.4 µg cm-2 h-1, respectively. Among the various CPEs used, propylene glycol and cetyl alcohol showed the highest and lowest enhancement on the skinpermeation of nitroglycerin, respectively. Oleic acid and cetyl alcohol moderately increased the skin permeation of nitroglycerin. It was also shown that increasing the concentration of CPE led to reduction in adhesion property of PSA as measured by 180° peeling strength test.