سال انتشار: ۱۳۸۷

محل انتشار: دومین کنگره بین المللی علوم و فناوری نانو

تعداد صفحات: ۲

نویسنده(ها):

M Hamidi – Department of Pharmaceutics, Faculty of Pharmacy, Shiraz University of Medical Sciences
H Salehi-Mansourkhani –
S Mohammadi-Samani –
M Kheirati –

چکیده:

The main principles in drug and gene delivery are to design systems that maintain the structure and activity of biomolecules are non-immunogenic, release the therapeutic agent predictably over time, and, finally, degrade to safe metabolites that are either absorbed or excreted [1]. Chitosan and alginate are two biopolymers that have received much attention and been extensively studied for drug delivery purposes. Nanoparticles made of polyelectrolyte complexation have shown potential for use as drug delivery systems. Polyelectrolyte complexes are formed when oppositely charged polyelectrolytes are mixed and interact via electrostatic interactions. Chitosan and alginate are polycation and polyanion polyelectrolytes, respectively, which can be used to form a polyelectrolyte complex and to deliver proteins, peptide drugs, and DNA.Chitosan is produced commercially by deacetylation of chitin, a structural element in the exoskeleton of crustaceans. The amino group in chitosan has a pKa value of ~6.5, thus, chitosan is positively charged and soluble in acidic to neutral solution with a charge density dependent on pH and the %DA-value. [2].The chemical compound sodium alginate is the sodium salt of alginic acid. Its form as a gum, when extracted from the cell walls of brown algae, is used by the foods industry to increase viscosity and as an emulsifier. [3, 4].The major goal of this study was to develop a novel type of hydrogel chitosan-alginate nanoparticle system as a vehicle for time/location controlled delivery of Desferrioxamine.