سال انتشار: ۱۳۸۳
محل انتشار: نهمین کنگره ملی مهندسی شیمی ایران
تعداد صفحات: ۶
Aghajani – Biotechnology group, Dept.of Chemiacl Engineering, School of engineering, Tarbiat Modarres University
Jahashahi – Nanoparticleslab, Dept.of Chemical Engineering, Faculty of engineering, University of Mazandaran (UMZ)
S.A. Shojaosadati – Biotechnology group, Dept.of Chemiacl Engineering, School of engineering, Tarbiat Modarres University
Pharmaceuical industry can widly use protein nanostructure because they mimic the drug delivery vehicles such as viruses,at the same time they are non-antigenic and biodegradable. This study objects to manufacture bovine serum albumin (BSA) nanoparticle by coacervation method following by crosslinking with glutaraldehyde. It is shown that the shape of nanoparticles is semispherical and the size distribution of them is 80- 280 nm. The mean size is 150 nm.The particl size is critical parameter in particular for invivo behaviour of nanoparticles after injection.