سال انتشار: ۱۳۸۸

محل انتشار: سومین کنفرانس نانوساختارها

تعداد صفحات: ۴

نویسنده(ها):

B Asadishad – Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran
M Vosoughi – Institute of Nanoscience, Sharif University of Technology, Tehran, Iran
I Alamzadeh – Biochemical and Bioenvironmental Research Center, Sharif University of Technology
A Tavakoli – Department of Chemical and Petroleum Engineering, Sharif University of Technology,

چکیده:

The chemical synthesis and in vitro drug delivery response of folate modified, polyethylene glycolfunctionalized gold nanoparticles were studied. Lysine-capped gold nanoparticles were first prepared. Subsequently the widely used anticancer agent doxorubicin (DOX) was successfully attached to the surface of folate modified, polyethylene glycol-functionalized gold nanoparticles. Fourier transform infrared spectroscopy (FTIR) and
transmission electron microscopy (TEM) were used to confirm the functionalization and conjugation steps in the chemical synthesis. The DOX-loading efficiency determined by UV–Vis spectrometer was 80%. Drug release experiments displayed a controlled-release behaviour that most of the conjugated doxorubicin was released within the first 12 h.