دانلود مقاله Theoretical Study of Using 2-Phenylthialcohols as Antidote Drugs. The Role of Stereochemistry.
سال انتشار: ۱۳۸۴
محل انتشار: چهارمین همایش ملی بیوتکنولوژی ایران
تعداد صفحات: ۳
Ali Amoozadeh – Semnan University, Department of Chemistry.
Parivash Peyvandi – Red Crescent Society of Semnan
There are some commercial antidote drugs like Dimercaprol, Succimer, or Penicilamine as parmaceutical chelators. They are bidental ligands which could give strong complexes with heavy metals as poisons. This paper introduces 2-Phenylthioalcohols as theoretically new antidote drugs and describes the role of stereochemistry on their effect. The stability of mentioned ligands and their complexes with are calculated by semi-empirical AM1 method and compared together and to ordinary used antidote drugs. Also the simple synthetic methods have introduced for their preparation. +2Zn